Radicle Proof Engine™

We’ve pioneered the first ever easy path for supplements products to clinically prove their true effects beyond placebo.

AI-driven, virtual, D2C clinical trials at unprecedented affordability, speed, and scale
Objective evidence to enable strong claims
Deep customer insights to drive revenue and increase CLV

The Radicle Proof Engine delivers gold standard IRB-approved double-blind, randomized, placebo-controlled clinical trials for supplement brands, manufacturers, and ingredient suppliers.

Pioneering Proof-as-a-Service

The Radicle Proof Engine delivers standardized trials that test your effectiveness on any of the following outcomes:

  • Cognition
  • Energy
  • General Discomfort
  • Gut Health
  • Immune Health
  • Mood and Feelings of Anxiety
  • Quality of Life and Overall Health
  • Sexual Health
  • Sleep
  • Stress

Products must be legal dietary supplements in orally ingestible form factors such as:

  • Capsules
  • Gummies
  • Tablets
  • Liquids
  • Lozenges
  • Strips
  • Powders
  • Softgels

Radicle Proof Engine™

Our Radicle Proof Engine enables validation of existing products in the market and discovery of the most effective products to bring to market.

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Radicle Validation is an Institutional Review Board (IRB)-approved, double-blind, randomized, placebo-controlled clinical trial to prove the true effects of your nonprescription supplement products.  

This gold-standard trial design generates the most objective data to enable strong claims and establish unique credibility with all stakeholders, from customers and retailers, to healthcare providers and investors.  Products must already be sold in the market to enroll in Radicle Validation.  

Generate objective evidence to enable strong structure/function claims
Drive revenue and customer lifetime value (CLV)
Minimum: six-week study duration, two arms (one placebo and one active product), and 250 participants per arm
Large sample size increases chance of outperforming placebo with statistical significance
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Radicle Discovery is a multi-arm double-blind, randomized controlled clinical trial enabling head-to-head comparisons of your nonprescription supplement products under development.  

Radicle Discovery allows you to explore multiple new formulations, form factors, and/or dosages to understand the true differences in effects and side effects.  Radicle Discovery trials can have numerous products simultaneously studied in parallel.

Rapidly compare multiple new formulations, form factors, and/or dosages
Guide customer and condition targeting
Accelerate new product development and bring the most effective product to market
Minimum: six-week study duration, two arms (one control and one active), and 250 participants per arm.
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The Radicle Way: A three-step path to clinically proven product claims

  1. Simply pick a product(s) and a condition
  2. We’ll run a large, gold standard clinical trial, end to end
  3. 120 days from participant trial start date, Radicle will deliver results to develop the most effective products & make strong claims

Standardized trials with 500 participants start at less than $100k.

Our partners and clients
Clean Label Project logo proof
open book logo
Nutraland tests its product with Radicle Proof Engine to generate strong structure/function claim.
Maypro supports Radicle Proof Engine to clinically prove the true effects of supplements products beyond placebo to unlock strong claims.
bioptimizers collaborates with Proof-as-a-Service company to help non-pharmaceuticals to clinically prove their true effects beyond placebo
rae logo proof
wholistic logo proof
anresco logo proof