A large-scale clinical study conducted by MDbio in partnership with Radicle Science, UCLA, the University of Maryland School of Medicine, and Harvard T.H. Chan School of Public Health, has revealed significant improvements in sleep onset and quality, as well as reductions in self-reported feelings of anxiety, stress, and overall well-being associated with two hemp/botanical preparations marketed as MDsleep. The study, involving 620 volunteers, is one of the largest double-blind, placebo-controlled trials of its kind, examining the effectiveness of non-melatonin dietary supplements for sleep improvement.

Volunteers were randomly assigned to receive a placebo or one of two MDsleep formulations, both containing legal cannabinoid limits and other botanical ingredients. The formulation with higher botanical content and lower THC levels demonstrated substantial improvements in sleep quality, anxiety, stress, and well-being, while the higher THC formulation showed no significant differences. These findings highlight the potential synergy between multiple botanical ingredients and the importance of precision dosing in formulating effective dietary supplements for sleep.

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