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Radicle Science works with supplement brands, contract manufacturers and ingredient suppliers. We have democratized the clinical study process, enabling any health and wellness brand – big or small – to undergo validation and prove their true effectiveness beyond placebo.

Radicle Science provides the first ever easy path for health and wellness products to prove their true effects beyond placebo. Radicle’s crowdsourced, virtual, direct-to-consumer (D2C) clinical studies deliver objective health outcome data across diverse conditions and populations – all at unprecedented affordability, speed, and scale. Since launching in 2021, Radicle conducted clinical studies on >20,000 Americans for clients ranging from startups to billion dollar publicly traded companies. Contact our team to learn how we can help your brand.

Radicle refers to the root of a plant, connecting to our mission to go back to the roots of mankind’s original medicines, heal with the roots of nature, and get to the root of the problem. Said out loud, it sounds like “Radical Science.” This serves as a constant reminder of our audacious business model and our radically disruptive approach, balanced by our commitment to scientific rigor and evidence.

All Radicle Science study templates are condition focused on a primary outcome while also including secondary and exploratory outcome measures in an effort to evaluate broader effects of the intervention. All of our studies are designed by renowned researchers who are experts in their field, often in collaboration with major academic institutions. The study templates are always reviewed and approved by a central Institutional Review Board (IRB) in accordance with federal regulations set forth by the FDA.

All Radicle Science study templates condition focused on a primary outcome while also including secondary and exploratory outcome measures in an effort to evaluate broader effects of the intervention. Our currently available study templates include sleep, stress/anxiety, pain, energy, appetite management, cognition and quality of life/overall health. New studies focused on digestive/gut health, immunity and women’s health will soon be available.

Radicle Science hasn’t implemented any biomarker testing at this time, as biomarkers aren’t appropriate for the currently available studies. Participant reported outcomes, or PROs, are the gold standard for the conditions we currently study. In the future, there may be studies where we incorporate biomarker testing.

Brand Report: Our Radicle Discovery Report provides a summary of the study outcomes. The report includes clinical study overview, statistical and clinical insights, usage patterns, and side effect profiles. Additionally, we deliver a clean annotated data set for any additional internal analysis.

BONUS: You’ll also receive a deep-dive consultation with representatives from our research and data science teams to answer questions about the report.

We are open to joint marketing events as well as media and press opportunities prior to and/or following the studies. Study information will never be shared without prior review and approval by the brand.

Radicle Science can work with your brand to create a manuscript for a potential peer-reviewed publication for an additional fee. Please keep in mind we can’t guarantee publication. Radicle Science is also happy to support our brand partners with press releases and other media coverage.

Radicle provides usage instructions on the study insert and via email. We ask about product usage in each survey, as well as side effects. We communicate with participants regularly to encourage and remind them to complete surveys.

We track how many surveys each participant completes, as well as make sure they understand how to take the products according to the manufacturers’ suggestions.

Radicle conducts all of its studies based on well supported scientific principles. The standard for substantiating structure/function claims for dietary supplements under FDA and FTC law is that the claim is supported by data that qualifies as “competent and reliable scientific evidence.” See the FDA’s Guidance for Industry: Substantiation for Dietary Supplement Claims Made Under Section 403(r) (6) of the Federal Food, Drug, and Cosmetic Act available here. (“The FTC has typically applied a substantiation standard of “competent and reliable scientific evidence” to claims about the benefits and safety of dietary supplements and other health-related products. The FDA intends to apply a standard for the substantiation of dietary supplement claims that is consistent with the FTC approach.”).

While Radicle believes that its evidence gathered generally qualifies as competent and reliable scientific evidence, only the FDA, the FTC, and the courts can make the final determination that any evidence is strong enough to substantiate a specific claim. As a result, you would need to check with your legal counsel to ensure that your expressed and implied claims about your product are adequately substantiated under all aspects of the law.

Please refer to this document for more information.

If the products are different in some way such as potency, formulation, or form factor, then evidence to support one product’s claim may not be applicable to the other, since there isn’t a guarantee both products will have the same effect.

Radicle Science offers a series of studies that provide deep customer insight for targeted marketing and generate objective evidence to enable strong claims.

Please refer to Our Offerings page to view the full list of Radicle research studies.

• Radicle Proof provides brand partners an opportunity to test commercial product(s) against a placebo control in a D2C virtual study format. Radicle Discovery provides brand partners the opportunity to test up to five new product formulations against a placebo control in the same D2C virtual format.
• Both Radicle Proof and Radicle Discovery studies are randomized, blinded studies that collect health outcome data from study participants using validated health indices, providing scientific rigor and the potential for statistically and clinically meaningful outcomes.
• Brand partners submit at least two arms (study product groups) for a Radicle Proof study:
  • An active (commercial) product arm
  • A matching placebo control arm
• For Radicle Discovery, brand partners submit:
  • At least one active product formulation and up to five unique formulations
  • A matching placebo control arm

All products must be the same product form and look the same (it is a blinded study) i.e., you cannot have three capsules, two gummies, and one oral spray (unless you will have a matching placebo for each product form). Similarly, you cannot have one red gummy, two yellow ones, and a green one.

The instructions for use for all your study arms (active arm(s) and placebo) must be the same.

• The instructions for use will determine the quantity you’ll supply to study volunteers. You’ll supply a quantity sufficient for the study duration, assuring the participant does not run out of product.

Radicle Science has a singular vision –we will challenge the status quo by democratizing the clinical study process and unleashing personalized health outcome data. Our vision is a future where affordable health and wellness products are trusted by patients, recommended by healthcare providers, reimbursed by insurance, and used as widely as pharmaceutical drugs.

A benefit corporation, or B-corp, is a for-profit corporation recognized by the majority of U.S. states that is driven by both mission and profit. Shareholders hold the company accountable to produce a financial profit as well as a specified public benefit. As a Delaware Public Benefit Corporation, our commitment to “increase public awareness of safe and affordable treatment options for the benefit of individuals who are in need of such treatments by studying and sharing objective health outcome data” is part of our corporate charter, as stated in our certificate of incorporation.